Salvage Ovarian FANG™ Vaccine + Bevacizumab

Exclusion Criteria

• •1. Surgery involving general anesthesia, chemotherapy, radiotherapy, steroid therapy, or immunotherapy within 4 weeks prior to vaccination. Chemotherapy within 3 weeks prior to vaccination. Steroid therapy within 1 week prior to vaccination.
• •2. Major surgery within 6 weeks or minor surgery within 2 weeks of receiving bevacizumab.
• •3. Patient must not have received any other investigational agents within 4 weeks prior to study entry.
• •4. Patients who require parenteral hydration of nutrition and have evidence of partial bowel obstruction or perforation.
• •5. Patients with history of brain metastases.
• •6. Patients with compromised pulmonary disease.
• •7. Short term (\<30 days) concurrent systemic steroids ≤ 0.25 mg/kg prednisone per day (maximum 7.5 mg/day) and bronchodilators (inhaled steroids) are permitted; other steroid regimens and/or immunosuppressives are excluded.
• •8. Prior splenectomy.
• •9. Prior malignancy (excluding nonmelanoma carcinomas of the skin and carcinoma in situ cervix) unless in remission for ≥ 2 years.
• •10. Kaposi's Sarcoma.
• •11. Patients with active bleeding or pathologic conditions that carry high risk of bleeding such as a known bleeding disorder, coagulopathy, or tumor involving major blood vessels.
• •12. History of Stroke/Transient Ischemic Attack
• •13. Use of bleeding diathesis
• •14. Use of anti-coagulants
• •15. Patients with clinically significant cardiovascular disease including any of the following:
• •1. Significant cardiac conduction abnormalities (e.g., PR interval \> 0.24 sec or second or third degree AV block.
• •2. Uncontrolled hypertension, defined as systolic blood pressure (BP) \> 150 mm Hg or diastolic BP \> 90 mm Hg.
• •3. Myocardial infarction, cardiac arrhythmia, or unstable angina within the past 6 months.
• •4. New York Heart Association grade II or greater congestive heart failure.
• •5. Serious cardiac arrhythmia requiring medication.
• •6. Grade II or greater peripheral vascular disease except episodes of ischemia \< 24 hours induration that are managed non-surgically and without permanent deficit
• •7. History of cerebrovascular accident within the past 6 months.
• •8. No significant traumatic injury within the past 28 days.
• •16. Uncontrolled infection or psychiatric illness/social situations that would limit compliance with study requirements.
• •17. Patients with known HIV.
• •18. Patients with chronic Hepatitis B and C infection.
• •19. Patients with uncontrolled autoimmune diseases.