RETIC Trial: Reversal of Trauma Induced Coagulopathy Using Coagulation Factor Concentrates or Fresh Frozen Plasma

Exclusion Criteria

• •1. Lethal injury
• •2. CPR on the scene,
• •3. Isolated brain injury, burn injury
• •4. Avalanche injury
• •5. Administration of FFP or coagulation factor concentrates before ED admission
• •6. Delayed (\> 6hours after trauma) admittance to ED
• •7. Known use of oral anticoagulants, or platelet aggregation inhibitors within 5 days before injury
• •8. Known history of severe allergic reaction to plasma products
• •9. Known history of congenital hemostasis disturbance, IgA or Protein C deficiency
• •10. Patients with a history of thromboembolic events or heparin induced thrombocytopenia (HIT) type 2 within the last year
• •11. Patients with a body weight \< 45kg and \> 150kg
• •12. Patients that are known to be pregnant
• •13. Jehova's Witness
• •14. Known participation in another clinical trial
• •15. Patient with known refusal of a participation in this clinical trial