Absence of Steroid in Renal Transplantation and Digital Fibrosis Observation

Exclusion Criteria

• •First renal transplant lost due to rejection,
• •Combined transplantation,
• •Previous history of transplantation other than kidney,
• •Non beating donor heart,
• •Presence of positive DSA by Luminex® regardless of the average of fluorescence (MFI),
• •Patients receiving corticosteroids at the time of transplantation,
• •Necessity to continue administration of systemic immunosuppressive treatment before transplantation,
• •Infections or severe diarrhea, vomiting, upper gastrointestinal tract malabsorption or active peptic ulcers, concomitant, significant and uncontrolled,
• •Subject or HIV positive donor,
• •Replicating viral hepatitis at the time of randomization,
• •Known allergy or intolerance to tacrolimus, macrolide, corticosteroids, mycophenolate mofetil or to any of the excipients,
• •Diagnosis of de novo malignancy prior to transplantation, with the exception of treated effectively basal cell or squamous cell carcinomas of the skin,- Current participation at another clinical study,
• •All clinical condition that the investigator considers incompatible with the conduct of the study in acceptable security conditions,
• •Inability of patient to comply with study procedures,
• •Pregnant or breast-feeding women,
• •Person placed under guardianship, under protection of law.