Cornea Preservation Time Study

Exclusion Criteria

• •Study Eye Eligibility Criteria
• •1. Prior EK
• •2. Indication for surgery that is not suitable for EK (e.g, keratoconus, stromal dystrophies and scars)
• •3. Presence of a condition that has a very high probability for failure (e.g., failed EK or Penetrating Keratoplasty (PKP), heavily vascularized cornea, uncontrolled uveitis)
• •4. Other primary endothelial dysfunction conditions including posterior polymorphous corneal dystrophy and congenital hereditary corneal dystrophy
• •5. Anterior chamber IOL in study eye prior to or anticipated during EK
• •6. Planned intraocular lens exchange of an anterior chamber IOL with a posterior chamber IOL in study eye at time of study EK
• •7. Pre-operative central sub-epithelial or stromal scarring that the investigator believes is visually significant and could impact post-operative stromal clarity assessment
• •8. Stromal vascularization that is visually significant (by investigator's judgment)
• •9. Presence of anterior synechiae (iris to cornea)
• •10. Peripheral anterior synechiae (iris to angle) in the angle greater than a total of three clock hours
• •11. Hypotony (Intraocular pressure \<10 mm Hg)
• •12. Uncontrolled (defined as intraocular pressure \> 25mm Hg) glaucoma with or without prior filtering surgery or shunt or mini-shunt placement.
• •* A shunt or mini-shunt is any device implanted to lower intraocular pressure through an external route (e.g Ahmed) or internal route (e.g. Glaukos) that is present in the anterior chamber angle or extends into the anterior chamber.
• •13. Controlled glaucoma with prior shunt or mini-shunt placement for glaucoma
• •* Note: FECD or pseudophakic/aphakic corneal edema with posterior chamber IOL that also have undergone filtering surgery (without shunt or mini-shunt) in which glaucoma is currently considered under control will be eligible
• •14. Fellow eye visual acuity \< 20/200 that is not correctable with EK
• •Eligibility Criteria for Second Study Eye
• •1. Study participant has already enrolled one eye
• •3. EK surgery in second eye is not planned within 6 weeks of EK on first study eye