Patients with primary CNS tumor or CNS tumor involvement. However patients with CNS metastases may be allowed if certain conditions are met.

Major surgery within 4 weeks before study treatment

Prior anaphylactic or other severe infusion reactions to human immunoglobulin or antibody formulations

Impaired cardiac functions

Previous hepatitis viral infection such as hepatitis B or hepatitis C

Diagnosis of HIV infection

Pregnant or nursing (lactating) women

First in Human Trial of TAS266 in Patients With Advanced Solid Tumors