Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Charite University, Berlin, Germany
With
Stanley Medical Research Institute
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Diagnosis of bipolar I or II disorder, currently depressive episode according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)
Hamilton Rating Scale for Depression (HAM-D) 17-item score ≥14, a HAM-D item 1 (depressed mood) score ≥2 at the screening and randomization visits
Young Mania Rating Scale (YMRS) score ≤12 at the screening and randomization visits.
Pretreatment with a mood stabilizer and/or an antidepressant at standard doses (Bauer et al. 2007a) for at least six weeks since the last dose adjustment, and for at least two weeks before enrollment
Serum levels of mood stabilizer were required to be within therapeutic ranges
TSH levels in normal range (serum TSH 0.3 - 4.7 mU/l)
You may not be if
Any axis I disorder other than bipolar disorder
Recent ultra-rapid cycling course (12 or more episodes in previous year), - - a diagnosis of substance dependence (DSM-IV) or substance use (except for nicotine) within 12 months before the screening visit
Clinically significant medical illness, especially severe cardiovascular diseases
Organic brain disorder
Current serious suicidal or homicidal risk by clinical judgment of the investigator
History of previous or current thyroid disease
Thyroid hormone treatment
Clareo Health | Supraphysiological Doses of Levothyroxine as Adjunctive Therapy in Bipolar Depression
