Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University Hospitals Cleveland Medical Center
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Able to provide informed consent before beginning any study-specific procedures
Male and female patients at least 18 years of age
Meets Diagnostic and Statistical Manual -IV criteria for BPI, BP II, or National Comorbidity Survey-R criteria for sub-threshold BP with or without symptoms, in need of medication adjustment(s)
Willing to be randomized to either Lithium or Quetiapine
If a sexually active female of childbearing potential, be using a reliable method of contraception, such as oral contraceptive or long-term injectable or implantable hormonal contraceptive, double-barrier methods (e.g. condom and diaphragm, condom and foam, condom and sponge), intrauterine devices, and tubal ligation
Women with reproductive potential must have a negative urine pregnancy test
You may not be if
Unwilling to comply with study requirements
Patients who have had severe adverse reaction to Lithium or Quetiapine
Pregnancy as determined by serum pregnancy test or breastfeeding
History of nonresponse to Lithium at doses \>900 mg ≥8 wks or to Quetiapine at doses of at least 300 mg/d ≥ 8 week for depression and at least 400-600 mg/d ≥ 4 wks for mania.
