A Randomized, Placebo-controlled, Double-blind Phase II Study Evaluating if Glucophage Can Avoid Liver Injury Due to Chemotherapy Associated Steatosis

Exclusion Criteria

• •Brain metastasis (if suspected, brain scan indicated)
• •Previous chemotherapy for the currently existing metastatic disease
• •Known or newly diagnosed diabetes
• •Patients with ACS within the last three months
• •Stage 3 or 4 heart failure defined according to the NYHA criteria
• •Uncontrolled angina
• •Contraindications to metformin (renal impairment \[eGFR \<45 mL/min/1.73m\^2\], known hypersensitivity to metformin, acute illness \[dehydration, severe infection, shock, acute cardiac failure\]), and suspected tissue hypoxia
• •Surgery (excl. diagnostic biopsy, central venous catheter) or irradiation within 2 weeks prior to study entry defined as given written informed consent
• •Concurrent chronic systemic immune therapy, chemotherapy, or hormone therapy not indicated in the study protocol
• •Administration of any investigational agent(s) within 4 weeks prior to study entry,
• •Previous exposure to EGFR-pathway targeting therapy
• •Acute or sub-acute intestinal occlusion or history of inflammatory bowel disease
• •Known grade 3 or 4 allergic reaction to any of the components of the treatment
• •Any concurrent malignancy other than non-melanoma skin cancer, or carcinoma in situ of the cervix. (Subjects with a previous malignancy but without evidence of disease for \>= 5 years will be allowed to enter the trial)
• •Pregnancy or lactation
• •Inadequate contraception (male or female patients) if of childbearing or procreative potential
• •Known drug abuse/ alcohol abuse
• •Legal incapacity or limited contractual capacity Medical or psychological condition which in the opinion of the investigator would not permit the patient to complete the study or sign meaningful informed consent