They have a mandatory \> 3 antihypertensive medication therapy, including a thiazide or a loop diuretic (according to the patient's renal function, unless documented side-effects) and at least one attempt to treat with spironolactone, given at usual recommended dose since at least 8 weeks, before inclusion,
A mandatory check list of secondary cause of hypertension has been excluded
They succeed the pill count test.
They have a mandatory ambulatory blood pressure monitoring before inclusion with at least 70% of valid readings during daytime (08:00 am 08:00 pm, using a sampling frequency of 20 minutes, only devices validated according to http://www.dableducational.org are permitted), where daytime ambulatory blood pressure of systolic and/or diastolic blood pressure exceeds 135 mmHg and/or 85 mmHg, respectively. Daytime ambulatory blood pressure of systolic and/or diastolic blood pressure below 135 mmHg and/or 85 mmHg, respectively, is acceptable for inclusion in the study if the patient takes four or more antihypertensive medication (3).
You may not be if
Patients with an eGFR \<30ml/min/m² are excluded,
patients with known renal atherosclerotic lesions,
previous procedures in the renal arteries,
known unsuitable anatomy for the procedure,
previous nephrectomy,
contrast agent allergy,
hyperthyroidia.
Clareo Health | Study of Catheter Based Renal Denervation Therapy in Hypertension
