Early Immune Responses to Inactivated Influenza Vaccine: a Pilot Study

Exclusion Criteria

• •1. Known to be pregnant.
• •2. Medical, behavioral, cognitive or psychiatric disease that in the opinion of the investigator affects the ability of the participant to understand and cooperate with the study protocol.
• •3. Severe allergy to eggs or any component of the influenza vaccine
• •4. Previous receipt of the 2011-2012 season influenza vaccine
• •5. Other condition that in the opinion of the investigator would jeopardize the safety or rights of a participant participating in the trial or would render the subject unable to comply with the protocol.
• •6. History of receiving any investigational product within the past 30 days.
• •7. Participant has had medical, occupational, or family problems as a result of alcohol or illicit drug use during the past 12 months.
• •8. History of a severe allergic reaction or anaphylaxis.
• •9. Pre-existing autoimmune or antibody-mediated diseases including but not limited to: systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, Sjögren's syndrome, or autoimmune thrombocytopenia.
• •10. Known immunodeficiency syndrome.
• •11. Use of chronic (≥14 days) oral or intravenous corticosteroids (excluding topical or nasal) at immunosuppressive doses (i.e. prednisone \>10 mg/ day) or immunosuppressive drugs within 30 days of starting this study.
• •12. Receipt of a live vaccine within past 4 weeks or a killed vaccine within past 2 weeks prior to entry into the study.
• •13. History of a surgical splenectomy.
• •14. Receipt of blood products within the past 6 months.
• •15. Refusal to allow storage of samples for future research.