have a primary diagnosis of asthma, chronic bronchitis or bronchiectasis

have had frequent COPD exacerbations within the past year

require mechanical ventilatory support

have a pretreatment DLCO \< 20% predicted or \> 60% predicted

have a pretreatment FEV1 \< 20% predicted AND homogeneous emphysema

have giant bullae

have undergone lung transplantation, lung volume reduction surgery, or lobectomy

are intolerant of corticosteroids or antibiotics

are pregnant or breast-feeding

Post Market Registry Study of the AeriSeal System