Clinical Trial of Simvastatin to Treat Generalized Vitiligo

Exclusion Criteria

• •history of segmental vitiligo
• •allergy to statin medications
• •use of statin medications due to cardiac risks.
• •use of any medications contraindicated with use of simvastatin
• •use of topical vitiligo treatments in past 4 weeks
• •use of laser or light-based vitiligo treatments within the past 8 weeks
• •treatment with immunomodulating oral medications in the past 4 weeks
• •use of statin medications in the past 8 weeks
• •evidence of hepatic dysfunction, personal or family history of non-alcoholic steatotic hepatitis, or personal history of hepatitis
• •evidence of renal dysfunction
• •history of myopathy or rhabdomyolysis, or elevated baseline creatinine kinase
• •recent history of alcohol or drug abuse
• •history of diabetes
• •untreated hypothyroidism
• •other conditions that require the use of interfering topical or systemic therapy
• •other current conditions that might interfere with study assessments such as, but not limited to, atopic dermatitis and psoriasis
• •clinically significant abnormal findings or conditions which might, in the opinion of the Principal Investigator, interfere with study evaluations or pose a risk to subject safety during the study.