Minocycline for Bipolar Depression

Exclusion Criteria

• •DSM-IV diagnosis of Bipolar NOS, Cyclothymia, or Schizoaffective Bipolar type
• •Pregnant women or women of child bearing potential who are not using a medically accepted means of contraception (defined as oral contraceptive pill or implant, condom, diaphragm, spermicide, IUD, s/p tubal ligation, partner with vasectomy)
• •Serious suicide or homicide risk
• •Unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurological, or hematological disease
• •Clinical or laboratory evidence of hypothyroidism; if maintained on thyroid medication must be euthyroid for at least 1 month before visit 1
• •Drug/alcohol dependence within past 30 days, or current substance use disorder that requires detoxification
• •Current use of minocycline or history of anaphylactic reaction or intolerance to minocycline
• •Primary clinical diagnosis of antisocial or borderline personality disorder
• •Patients with metallic foreign bodies or claustrophobia will be excluded from the MRS component