Efficacy Of Pf-04531083 In Treating Post-Surgical Dental Pain

Exclusion Criteria

• •Presence or history of any significant hepatic, renal, endocrine, cardiovascular, neurological (including subjects with a history of frequent moderate to severe headaches or subjects with episodic migraines more than twice per month), psychiatric, gastrointestinal, pulmonary, hematologic, or metabolic disorder.
• •Prior use of any type of analgesic or NSAID within five half-lives of that drug or less before taking the first dose of study medication, except for anesthesia for the procedure.
• •Recent history of chronic analgesic or tranquilizer dependency.
• •Active dental infection at the time of surgery.
• •Any significant oral surgery complication at the time of surgery or in the immediate postoperative period or dental surgery lasting \> 30 minutes.
• •Subjects who are smokers.