Rapid Oral Test for Therapeutic Response in HIV/AIDS Patients

Inclusion Criteria

• •Group 1, cART-unresponsive
• •Documented HIV-positive before obtaining AIDS diagnosis
• •cART for 18 months or longer
• •consistent lab tests in previous 3-6 months: \< or equal to 200 CD4 T cells/mm3, viral load \>5000 HIV RNA copies/ml
• •Group 2, cART-responsive
• •Documented HIV-positive before obtaining AIDS diagnosis
• •cART for 18 months or longer
• •consistent lab tests in previous 3-6 months: \> or equal to 350 CD4 T cells/mm3, viral load \< or equal to 50 HIV RNA copies/ml
• •Group 3, acute/early HIV
• •Acute HIV:
• •Signs and symptoms of acute retroviral syndrome in a person with either a negative or evolving antibody response (western blot or ELISA) in presence of a positive HIV p24gag antigen or HIV-1 proviral DNA PCR or positive HIV-1 RNA
• •Early HIV:
• •A positive antibody response (western blot or ELISA) with a documented negative serological test or plasma HIV-1 RNA within the past 12 months or a positive ELISA and a negative de-tuned ELISA within 30 days of a positive ELISA specimen in an untreated person with no clinical or immunological evidence of advanced HIV disease (CD4 count \>200 cells/mm3 or \>14%)
• •Group 4, HIV-negative Hepatitis-positive
• •HIV test negative (western blot, ELISA or viral load)
• •Positive Hepatitis B surface antigen and detectable hepatitis B viral load (HCV B RNA), treated or not OR Positive Hepatitis C antibodies and detectable hepatitis C viral load (HCV C RNA), treated or not