Lead Sponsor

Abbott

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Age is greater than or equal to 18 years.
•2. Subject must have a histologically or cytologically confirmed non-hematologic malignancy other than Hepatocellular Carcinoma (HCC).
•3. Eastern Cooperative Oncology Group (ECOG) Performance Score of 0-2.
•4. Subject must have adequate bone marrow, renal and hepatic function as follows:
•* Bone Marrow: Absolute neutrophil count (ANC) \>= 1,500/mm3 (1.5 X 109/L); Platelets \>= 75,000/mm3 (75 X 109/L); Hemoglobin \>= 9.0 g/dL (1.4 mmol/L)
•* Renal function: serum creatinine \<= 2.0 mg/dL (0.81 mmol/L);
•* Hepatic function: AST and ALT \<= 1.5 X ULN unless liver metastases are present, then AST and ALT \<= 5.0 X ULN; bilirubin \<= 1.5 mg/dL (0.026 mmol/L)
•5. Subject must have Partial Thromboplastin Time (PTT) \</= 1.5 x Upper Limit of Normal ( ULN) and International Normalized Ratio (INR) \</= 1.5.

•1. Subject has received anti-cancer therapy including investigational agents, cytotoxic chemotherapy, radiation therapy or biologic therapy within 21 days or within a period defined by 5 half lives, whichever is shorter, prior to study drug administration. In addition subject has not recovered to less than or equal to Grade 1 clinically significant adverse effects/toxicities of the previous therapy.
•2. Subject has undergone major surgery within 21 days of Period 1, Study Day 1.
•3. Subject has untreated brain or meningeal metastases. Subjects with treated brain metastases that are radiographically or clinically stable (for at least 4 weeks after therapy) and who have no evidence of cavitation or hemorrhage in the brain lesion, are eligible provided that they are asymptomatic and do not require corticosteroids (must have discontinued steroids at least 1 week prior to Study Day 1, Period 1).
•4. Current enrollment in another clinical trial.

Related studies

NCT06248411 · Advanced or Metastatic Solid Tumors

NCT06716138 · Locally Advanced or Metastatic Solid Tumors Harboring a ROS1 or NTRK Alteration

NCT06307795 · Locally Advanced or Metastatic Solid Tumors

NCT05753722 · Advanced or Metastatic Solid Tumors, Non Small Cell Lung Cancer, and more

NCT05581004 · Locally Advanced or Metastatic Solid Tumors, NSCLC, and more

A Study Evaluating the Bioavailability of Two Formulations of Linifanib and Food Effect on Pharmacokinetics of Linifanib in Subjects With Advanced or Metastatic Solid Tumors