Adding Liraglutide to High Dose Insulin: Breaking the Cycle

Exclusion Criteria

• •Type 1 diabetes mellitus
• •Any contraindication to the MRI procedure (metallic implants, severe claustrophobia, pregnancy, unable to lie still on a hard table for the duration of the procedure, weight above 400 lb - limit of the MRI table, magnet's inner circumference smaller than the largest body circumference)
• •History of any pancreatic disease as it might interfere with the pancreatic TG measurement (i.e. pancreatitis, tumors, cysts, type 1 diabetes, any pancreatic surgery)
• •End Stage Renal Disease on dialysis due to increased risk of hypoglycemia, and possible interference with accurate measurement of HbA1c
• •Incretin therapy (any GLP-1 agonist or DPP-IV inhibitor)
• •Unstable or decompensated comorbidities
• •Personal or family history of medullary thyroid carcinoma or MEN-2 syndrome
• •Severe gastroparesis
• •Pregnancy, breast feeding, intention to become pregnant, or not using adequate contraceptive measures
• •Organ transplant recipient or waiting list candidate
• •Steroid use (current or potential use during the trial)
• •Known/suspected allergy to trial medication, excipients, or related products
• •Contraindications to study medications, worded specifically as stated in the product's prescribing information
• •Non-English speaking volunteers since no interpreters are available and the safety of the volunteers could be jeopardized if adequate and reliable communication is not possible.