Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients must have clinically documented primary brain tumor for which resection is clinically indicated. Radiographic findings should be consistent with high grade glioma. Intraoperative frozen section should either be: anaplastic astrocytoma (WHO Grade III astrocytoma) or glioblastoma (WHO Grade IV astrocytoma).
Patients must be aged greater than 18 years old
Karnofsky Performance Score \> 70 (Appendix)
Patients must have normal organ and marrow function as defined below:
* Leukocytes \> 3,000 /uL
* Absolute neutrophil count \> 1,500/uL
* Platelets \> 100,000/uL
* Total bilirubin within normal institutional limits
* AST/ALT within normal institutional limits
* Creatinine within normal institutional limits
You may not be if
Prior craniotomy for resection, deep seated tumors in thalamus and brain stem.
History of allergic reactions to compounds of similar chemical composition to ALA.
Personal or family history of porphyrias
Personal history of hepatitis or other liver diseases.
Pregnant women are excluded from this study because ALA is of unknown teratogenic effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with ALA, breastfeeding should be discontinued prior to treatment with ALA.
Inability to undergo magnetic resonance imaging (i.e. those patients with AICD/pacemakers).
Clareo Health | Phase I Study of Orally Administered Aminolevulinic Acid for Resection of Malignant Astrocytomas
