Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Vertex Pharmaceuticals Incorporated
Age
18–64
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Males or females aged 18 to 64 years with a body mass index between 18 and 35 (kg/m2)
Subjects who have completed the assigned study treatment in Part A may enter Part B if eligible per protocol
Male or female subjects must agree to use acceptable contraceptive methods, as described in the protocol
Must have a diagnosis and history of treatment-resistant partial-onset epilepsy for which they are taking 1 to 4 concomitant AEDs at the time of Screening Period
Have had at least 1 electroencephalogram consistent with partial epilepsy
Must have had at least 6 partial-onset seizures and a seizure-free period of no more than 3 weeks (21 days) during the Baseline Period.
Subjects with stable medical conditions (e.g., cannot have a condition that will interfere with the conduct of the study or cause a known increase in risk of the intervention) as determined by the principal investigator
Must be able and willing to provide written informed consent to participate
Must be able to understand and comply with protocol requirements and instructions
You may not be if
Subjects who are male and their female partner (if of childbearing potential) does not agree to use medically approved methods of contraception as described in the protocol for the duration od the study and for 90 days after last dose of study drug
Subjects who are male and have a female partner who is pregnant, nursing, or is planning to become pregnant during the study period, or within 90 days of the last dose of study drug.
Subjects who are pregnant or lactating, or who are of reproductive potential who do not agree to use medically approved birth control methods
History of nonepileptic, transient alterations in consciousness
History of status epilepticus in the past 12 months before the screening visit
Subjects whose seizure frequency cannot be quantified (i.e. seizures with no discrete beginning or end, or period between seizures)
Subjects who have a significant medical illness including kidney, liver, pulmonary, or gastrointestinal disease; or unstable or poorly controlled conditions such as hypertension, diabetes, or angina pectoris, as judged by the investigator.
Have a clinically significant psychiatric illness as judged by the investigator
Subjects who have had an active suicidal plan/intent or active suicidal thoughts, or suicide attempt as defined in the protocol
Clinically significant laboratory abnormalities during the Screening Visit/Baseline Period, as judged by the investigator
Subjects who have had serious adverse events (SAEs) thought to be related to study drug that led to discontinuation during Part A may not participate in Part B
Active hepatitis B, hepatitis C, or human immunodeficiency virus
Positive drug screen at screening or during the Baseline Period (excluding any allowed prescribed medications) and/or a history of alcoholism or drug addiction within past 2 years
Subjects on felbamate with fewer than 18 month of continuous felbamate exposure at the time of the Screening Visit or with significant adverse reactions to felbamate
Subjects treated with vigabatrin fewer than 2 years prior to the Screening Visit or who have a prior history of treatment with vigabatrin without a documented stable examination by an ophthalmologist as defined in the protocol
Using prohibited medications or treated with any systemic immunosuppressant
Have experienced a symptomatic viral, fungal, or bacterial infection requiring systemic treatment within 7 days prior to the first dose of study drug
A current or prior history of illness precluding them from immunomodulatory therapy (e.g., history of recurrent infections)
Have donated any blood or have had a significant loss of blood (500 mL) as defined in the protocol
Have participated in any other clinical studies involving an investigational product or device and have received the last dose of the study drug associated with that clinical study within 30 days or 5 half-lives (whichever is longer) of the Screening Visit
Have participated in earlier VX-765 clinical studies and received at least one dose of study drug
Subjects who have no completed the full 13-week Treatment Period in part A may not participate in Part B
Any subject judged by the investigator, sponsor or designee to be inappropriate for the study
Clareo Health | A Study to Evaluate the Efficacy and Safety of VX-765 in Subjects With Treatment-Resistant Partial Epilepsy
