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Keep this study
Lead
AstraZeneca
Phase II Trial to Evaluate the Efficacy of Fostamatinib in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Aged at least 18 years of age.
Patients with relapsed or refractory diffuse large B-cell lymphoma who have previously received R-CHOP (or equivalent) chemo-immunotherapy and high dose chemotherapy with stem cell rescue, or who are ineligible for high dose therapy with stem cell rescue.
Measurable disease as defined by Cheson et al 2007 criteria.
One fresh pre-treatment excisional or core needle biopsy from suitable and accessible site.
World Health Organization (WHO) performance status 0 to 1.
You may not be if
Treatment with nitrosurea, mitomycin C, investigational agents or study drugs w/in28 days of first dose of study treatment, any other chemotherapy, immunotherapy or anticancer agents w/in 3 weeks of first dose of study treatment, previous fostamatinib.
With the exception of alopecia, any unresolved toxicities from prior therapy or surgery greater than Common Terminology Criteria for Adverse Events (CTCAE) Grade 1.
Uncontrolled hypertension (defined as \>140mmHg systolic and/or \> 90 mmHG diastolic at baseline with or without antihypertensive therapy.
Evidence of tuberculosis (TB).
Inadequate boen marrow reserve.
Clareo Health | Study to Learn if 200mg Test Drug (Fostamatinib) Helps People With Large B-Cell Lymphoma,a Type of Blood Cancer
