Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies

Inclusion Criteria

• •Patients with the following diseases:
• •* Acute myeloid or lymphocytic leukemia in first remission at standard or high-risk for recurrence.
• •* Acute leukemia in greater than or equal to second remission, or with early relapse, or partial remission.
• •* Chronic myelogenous leukemia in accelerated phase or blast-crisis.
• •* Chronic myelogenous leukemia in chronic phase
• •* Recurrent or refractory malignant lymphoma or Hodgkin's disease
• •* Multiple myeloma.
• •* Chronic lymphocytic leukemia, relapsed or with poor prognostic features.
• •* Myeloproliferative disorder (polycythemia vera, myelofibrosis) with poor prognostic features.
• •* Severe aplastic anemia after failure of immunosuppressive therapy.
• •Age 10-65 years.
• •Zubrod performance status less than or equal to 2.
• •Adequate cardiac and pulmonary function. Patients with decreased LVEF \< 40% or DLCO \< 50% of predicted will be evaluated by cardiology or pulmonary prior to enrollment on this protocol.
• •Patient or guardian able to sign informed consent.