MEDI-573 in Combination With SOC in Unresectable or Metastatic HCC.

Exclusion Criteria

• •Child-Pugh Score for Cirrhosis Mortality \> 7 points
• •Prior or current system anti-cancer therapy for HCC, including cytotoxic, biologic, targeted or experimental therapy
• •Prior local treatment for HCC less than 4 weeks prior to initiating study treatment
• •Active second malignancy
• •Major surgery, open biopsy or significant traumatic injury within 4 weeks prior to initiating study treatment
• •Thrombotic or embolic events within 6 months prior to initiating study treatment
• •Ongoing pancreatitis
• •Uncontrolled or refractory ascites
• •Evidence of ongoing spinal cord compression, known carcinomatous meningitis, or known leptomeningeal carcinomatosis
• •Hepatic encephalopathy \> Grade 1
• •Active brain metastases with exceptions
• •Poorly controlled diabetes mellitus
• •Active coronary artery disease
• •Uncontrolled hypertension