Open-Label Hepatic Impairment Study

Exclusion Criteria

• •Prior PEG/RBV null responders.
• •Unstable cardiac disease, recent Myocardial infarction, or family history of QTc prolongation or unexplained cardiac arrest.
• •Positive test at Screening for anti-HAV IgM Ab, HBsAg, anti-HBc IgM Ab, or anti-human immunodeficiency virus (HIV) Ab.
• •History of clinically significant medical condition associated with other chronic liver disease
• •Any current signs or symptoms of severe hepatic encephalopathy
• •History of gastric or esophageal variceal bleeding in which varices have not been adequately treated with medication and surgical procedures
• •Prior placement of a portosystemic shunt
• •History of hepatorenal, or hepatopulmonary syndrome.
• •Active spontaneous bacterial peritonitis.
• •Use of medications associated with QT prolongation within 28 days prior to dosing.
• •Current Hypotension
• •History of Torsades de Pointes, evidence of an active or suspected cancer, or a history of malignancy, Abnormal hematological and biochemical parameters