Epilepsy secondary to progressive cerebral disease, tumor or any progressive neurodegenerative disease.

History of status epilepticus in the last six months.

Currently treated with felbamate or has been treated with vigabatrin within the past 6 months.

Following the ketogenic diet.

Suicidal intent or history of suicide attempt in the last 2 years.

Elevated liver enzymes or abnormal kidney function.

Current disturbance of micturition or known urinary obstructions.

History of vesicoureteric reflux.

Abnormal post-void residual bladder ultrasound.

Urinary retention and/or required urinary catheterization in the preceding 6 months.

Abnormal urine sample at screening/.baseline.

Abnormal blood sample at screening.

Clinically significant arrhythmias.

Abnormal ECG at screening.

BMI lower than the 10th percentile for age and gender or subject weighs less than 30kg.

Study in Pediatric Subjects With Epilepsy