Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Lexicon Pharmaceuticals
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male and female subjects, aged 18 to 70 years, with diarrhea-predominant IBS (IBS-D) with symptom onset at least 6 months prior to diagnosis
Two or more days per week with at least one stool with a consistency of Type 6 or 7 (Bristol Stool Form Scale)
Weekly average of worst abdominal pain in past 24 hours score of greater than or equal to 3.0 using a 0-10 point scale
Ability to provide written, informed consent
You may not be if
Inability to discontinue any current drug therapy for IBS, with the exception of bulking agents. Subjects will be allowed up to 2 doses of loperamide per week as rescue medication.
Subjects who score severe abdominal pain (rated 7 or higher) 5 or more days per week
Concomitant use of opioid analgesic drugs or drugs that affect bowel motility
Any abnormalities or conditions deemed by the investigator as clinically significant
