Tenofovir in Late Pregnancy to Prevent Vertical Transmission of Hepatitis B Virus

Exclusion Criteria

• •co-infection with hepatitis A, C, D, E, HIV-1 or sexually transmitted disease (STD)
• •decompensated liver disease or significant co-morbidity
• •history of abortion, or diagnosis of fetal defect, or congenital malformation in prior pregnancy
• •antiviral used within six months prior to this pregnancy, or history of renal or tubular function impairment due to adefovir.
• •requirement for other medication during pregnancy to manage other chronic disease(s) or concurrent treatment with immune-modulators, cytotoxic drugs, or steroids
• •the biological father of the child had CHB
• •clinical signs of threatened miscarriage in early pregnancy
• •evidence of hepatocellular carcinoma
• •maternal alanine aminotransferase (ALT) \> or = 5 x upper limit of normal (U/mL), or Total Bilirubin \> or = 2, or glomerular filtration rate (GFR) \< 100, or Albumin \< 25 g/L
• •evidence of fetal deformity by ultrasound examination
• •patient is participating other clinical study