Open-Label Pilot Study of Lisdexamfetamine for Cocaine Dependence

Exclusion Criteria

• •Individuals who meet DSM-IV-TR criteria for bipolar disorder, schizophrenia, any psychotic disorder other than transient psychosis due to drug abuse, or current major depressive disorder
• •Individuals with any other current Axis I psychiatric disorder as defined by DSM-IV-TR that in the investigator's judgment are unstable, or would be disrupted by study medication, or are likely to require pharmacotherapy during the study period
• •Individuals physiologically dependent on any other drugs (excluding nicotine or cannabis) which require medical intervention
• •Individuals with current psychostimulant abuse or dependence (other than cocaine dependence)
• •Individuals with current suicidal risk
• •Individuals with coronary vascular disease as indicated by history or suspected by abnormal ECG or history of cardiac symptoms
• •Unstable physical disorders which might make participation hazardous such as uncontrolled hypertension (SBP \> 140, DBP\> 90, or HR \> 100 when sitting quietly), acute hepatitis (patients with chronic mildly elevated transaminases \< 1.5x upper limit of normal are acceptable), or uncontrolled diabetes
• •Individuals with a history of seizures, hyperthyroidism and/or glaucoma
• •Individuals with a family history of sudden cardiac death
• •History of allergic reaction to study medication
• •Women who are pregnant or nursing
• •Currently being prescribed psychotropic medication by another physician (other than sleep medication)
• •Individuals who are legally mandated (e.g., to avoid incarceration) to participate in substance abuse treatment program