Akt Inhibitor MK2206 in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Exclusion Criteria

• •Tumor tissue sample must be available for pathological review
• •No known CNS involvement
• •ECOG performance status \< 2 (Karnofsky \> 60%)
• •Life expectancy \> 4 months
• •Absolute neutrophil count \>= 1,500/µL
• •Platelets \>= 100,000/µL (\>= 75,000/µL if the bone marrow is involved)
• •Total bilirubin =\< 1.5 X institutional upper limit of normal (ULN)
• •AST(SGOT)/ALT(SGPT) =\< 2.5 X ULN
• •Calculated creatinine clearance \>= 50 mL/min
• •Not pregnant or nursing
• •Negative pregnancy test
• •Women of child-bearing potential and men must agree to use adequate contraception
• •Must be able to swallow whole tablets
• •* Nasogastric or G-tube administration is not allowed
• •* Tablets must not be crushed or chewed
• •Patients with French Social Security in compliance with the French law relating to biomedical research allowed
• •No history of allergic reactions attributed to compounds of similar chemical or biologic composition to MK2206 tablets
• •Hyperglycemia should be well controlled on oral agents
• •Cardiovascular baseline QTcF =\< 450 msec (male) or QTcF =\< 470 msec (female)
• •No uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• •No HIV-positive patients on combination antiretroviral therapy
• •No patients with malabsorption syndrome or other condition that would interfere with intestinal absorption
• •No patients with clinically important history of liver disease, including viral or other hepatitis or cirrhosis
• •No prior history of malignancies other than lymphoma (except for basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix or breast) unless the subject has been free of the disease for \>= 3 years
• •Must have recovered from adverse events due to agents administered more than 4 weeks earlier
• •Patients must have discontinued all prior therapies for at least 5 times the half-life of all prior anticancer therapies before study entry
• •Prior treatment could include high-dose chemotherapy with autologous stem-cell transplantation if patients had progressed \>= 3 months after this treatment
• •No chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C)
• •Patients must not be receiving any other investigational agents
• •No other investigational or commercial agents or therapies may be administered with the intent to treat the patient's malignancy
• •No concurrent radiotherapy