Evaluation With CT Scan of Possible Changes in Airways After Treatment With Daxas® in Severe Chronic Obstructive Pulmonary Disease Patients

Inclusion Criteria

• •Male or female patient ≥ 30 years old
• •Patient with BMI ≥ 20
• •Written informed consent obtained
• •Female patient of childbearing potential who confirm that a contraception method was used at least 14 days before visit 1 and will continue to use a contraception method during the study.
• •Patient should be treated according to GOLD guidelines
• •COPD patient with GOLD stages III until IV
• •Patient with smoking history of at least 10 pack-years
• •Patient takes Spiriva® and a fixed combination of inhaled steroids and long acting beta agonist (LABA) at least 6 weeks before visit 1
• •Patient must be able to understand and complete the protocol requirements, instructions, questionnaires and protocol-stated restrictions.