Medications: oral steroidal anti-inflammatory, anti-osteoporotic treatment, hormone replacement therapy

Low bone mineral density (T-score\<-3

Diseases affecting bone metabolism(Paget's disease, Cushing's disease, thyroid disease...)

Intolerance or allergy to milk proteins and allergy to soy or soy lecithin

Heavy smoking

Excessive alcohol drinking

Intensive sports practice according to the investigator

Effects of Proteins Fraction Derived From Milk on Osteoporosis Prevention