18 to 64 years old, IQ≥85 and estimated Glomerular Filtration Rate (GFR) \< or =60. All oral and depot antipsychotics (with the exception of clozapine) are allowable.
Patients must be on their antipsychotic medication for 1 month and stable on dose of antipsychotic and adjunctive medications for 2 weeks prior to study entry.
You may not be if
Include a history of neurological visual or hearing impairment, active suicidal ideation on the Calgary Depression Scale (CDS), current alcohol or drug abuse (\<1 month) or substance dependence (\<4 months).
All women of child-bearing potential must have a negative serum pregnancy test at the baseline visit.
We require an IQ of greater or equal to 85 to ensure that subjects will have a capacity to learn.
In our cross-sectional studies, we have observed an IQ greater than 85 in over 90% of candidates, suggesting that this is not an overly restrictive criterion.
