Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic Treatment

Exclusion Criteria

• •1. Acute coronary syndromes
• •2. Renal insufficiency with a sCr ≥ 3.0 mg/dl or planned renal replacement therapies
• •3. Systolic blood pressure \< 90 mmHg at time of enrollment
• •4. Pulmonary Arterial Hypertension not secondary to left heart disease
• •5. Contraindications to systemic anticoagulation
• •6. Hematocrit \> 45%
• •7. Inability to obtain venous access
• •8. Hemodynamic instability severe enough to require IV positive inotropic agents, IV vasodilators or both
• •9. Use of iodinated radiocontrast material within the previous 72 hours or planned study requiring IV contrast during the current hospitalization
• •10. Severe concomitant disease expected to prolong hospitalization
• •11. Severe concomitant disease expected to cause death in ≤ 90 days
• •12. Sepsis or ongoing systemic infection
• •13. Severe uncorrected valvular stenosis
• •14. Active myocarditis
• •15. Hypertrophic obstructive cardiomyopathy
• •16. Constrictive pericarditis or restrictive cardiomyopathy
• •17. Liver cirrhosis
• •18. Previous solid organ transplant
• •19. Requirement for mechanical ventilatory support
• •20. Presence of a mechanical circulatory support device
• •21. Unwillingness or inability to complete follow up
• •22. Active drug or ETOH substance abuse
• •23. Participating in another interventional clinical trial