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Extubation Readiness Study in Very Low Birthweight Infants | Clinical Trials | Clareo Health

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Extubation Readiness Study in Very Low Birthweight Infants

A Randomized Trial of the Spontaneous Breathing Trial to Extubate Very Low Birthweight Infants

NCT01471431•University of Pennsylvania

Summary

The objective of this study is to determine whether use of the spontaneous breathing trial allows for earlier successful extubation of very low birth weight (VLBW) infants who are intubated for \>48 hours and have not yet been successfully extubated (extubated \>7 days).

Eligibility

Age

0 - 0 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Birthweight \>500g and\<1500g.
•Postmenstrual age \<34 weeks
•Mechanically ventilated \>48 hours
•Never successfully extubated

Exclusion Criteria

•Congenital heart disease (other than patent ductus arteriosus (PDA), patent foramen ovale (PFO), and restrictive ventricular septal defect (VSD)
•Known or suspected airway anomalies
•Severe congenital malformations
•Need to remain intubated for other reasons (i.e. having surgery)
•Has met SBT criteria on previous calendar day (after 48 hrs of ventilation, PIP≤18, PEEP≤6, FiO2≤40%, Rate≤30, PS≤8)

Locations (2)

The Hospital of the University of Pennsylvania

Phialdelphia, Pennsylvania, United States

Pennsylvania Hospital

Philadelphia, Pennsylvania, United States

Key Dates

Start Date

August 1, 2011

Primary Completion Date

April 1, 2016

Completion Date

April 1, 2016

Last Updated

June 7, 2016

Enrollment

ACTUAL participants

Conditions

Respiratory Distress Syndrome

Interventions

spontaneous breathing trial

OTHER

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Acute Respiratory Distress SyndromeRight Heart Failure

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 7, 2016Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Extubation Readiness Study in Very Low Birthweight Infants

Inclusion Criteria

Exclusion Criteria

Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome

Turning Ratios Into Prognosis: Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Powerful Predictors of ARDS in Pediatric Burn Patients: A Prospective Evaluation

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

Assessment of Airway Opening Pressure in Invasively Ventilated Children

Vadadustat for the Treatment of Nonintubated Acute Respiratory Distress Syndrome Due to Pathogen-Associated Lung Injury

LUng and Cardiac Ultrasound for REspiratory Distress in ElDerly