Lead Sponsor

Sheffield Children's NHS Foundation Trust

Collaborators

Age

0 - 1 years

Sex

ALL

Healthy Volunteers

Yes

•Previously healthy infants under 1 year of age
•Admitted to hospital with a clinical diagnosis of acute bronchiolitis, following the UK definition of an infant with an apparent viral respiratory tract infection associated with airways obstruction manifest by hyperinflation, tachypnoea and subcostal recession with widespread crepitations on auscultation
•Requiring supplemental oxygen therapy on admission

•Wheezy bronchitis or asthma - children with an apparent viral respiratory infection and wheeze with no or occasional crepitations
•Previous lower respiratory tract infections
•Risk factors for severe disease \[gestation \<32 weeks, immunodeficiency, neurological and cardiac conditions, chronic lung disease\]
•Subjects where the carer's English is not fluent and translational services are not available
•Requiring admission to high dependency or intensive care units at the time of recruitment