Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of California, San Francisco
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Healthy individuals, male or female, age 18-65 years old, with no current medical conditions or active diagnoses as determined by the study doctor based on history, physical exam and laboratory evaluations
Subjects that take no other medications 2 weeks prior to the study and during the time course of the study including prescription medications, over-the-counter medications (except acetaminophen), dietary supplements, or drugs of abuse
Subjects with a SLCO1B1\*1A genotype
Subjects able to maintain adequate birth control during the study independent of hormonal contraceptive use
Subjects able to abstain from grapefruit, grapefruit juice, orange juice, caffeinated beverages and/or alcoholic beverages from 3 pm the day before the study to completion of that study day.
Participants determined to have normal liver and kidney function as measured at baseline
BMI between 18.5 - 30 kg/m2
Subjects capable of fasting from food and beverages at least 8 hours prior to medication dosing
Be able to read, speak, and understand English
You may not be if
Subjects with active medical problems
Subjects on chronic prescription or OTC medications that cannot be stopped 2 weeks prior to and during the study.
Subjects incapable of multiple blood draws (HCT \<30 mg/dL)
Subjects with a history of rhabdomyolysis
Subjects with a history of drug-related myalgias
Subjects with a history or diagnosis of hemorrhagic tendencies or blood dyscrasias
Subjects with a history of GI bleed or peptic ulcer disease
Subjects with a recent history of trauma
Subjects with a recent history of or upcoming plan of surgery
Subjects that smoke tobacco or have ongoing alcohol or illegal drug use
Subjects who are pregnant, lactating, or trying to conceive during the study period
Subjects allergic to rosuvastatin or clopidogrel or any known component of the medications
