\- Severe lung or bronchial disease (FEV1 \<60%)

Systolic LV dysfunction (LVEF \<50%) or diastolic dysfunction \> grade I

Valvular defect \> grade I (except for tricuspid- or pulmonary insufficiency)

Uncontrolled systemic arterial hypertension (at rest \>150 mmHg systolic or 95 mmHg diastolic)

Uncontrolled ventricular arrhythmias

Uncontrolled bradycardia or tachycardia supraventricular arrhythmias

Myocardial infarction within the last 12 months

Pulmonary embolism within the last 12 months

Relevant changes in hemodynamic therapy or major surgery within the last 12 weeks

Musculoskeletal or peripheral vessel disorders which complicates an ergometry

Hemodynamic Changes in Connective Tissue Disease