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Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases | Clinical Trials | Clareo Health

COMPLETEDNA

Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases

Hypercapnia During Thoracoscopy or Open Surgery for Repair of Oesophageal Atresia With Tracheo-oesophageal Fistula or Congenital Diaphragmatic Hernia in Neonates: Pilot Randomised Controlled Trial

NCT01467245•Great Ormond Street Hospital for Children NHS Foundation Trust

View on ClinicalTrials.gov

Summary

This is a pilot randomised controlled trial comparing open versus thoracoscopic surgery for repair of oesophageal atresia with tracheo-oesophageal fistula or congenital diaphragmatic hernia in neonates. Thoracoscopic surgery involves insufflation of carbon dioxide into the thoracic cavity and may therefore cause hypercapnia and acidosis.

Eligibility

Age

0 - 0 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Neonates with diagnosis of oesophageal atresia with tracheo-oesophageal fistula or congenital diaphragmatic hernia
•-\>1.6 Kg
•Conventional ventilation (no high frequency ventilation or iNO) for at least 24 hours.
•FiO2 \<0.4
•No requirement for inotropes for at least 24 hours

Exclusion Criteria

•Late diagnosis (after 1 month of age)
•Major congenital heart defects or pulmonary hypertension
•Bilateral grade IV intraventricular haemorrhage
•Previous ECMO
•FiO2 ≥ 0.4

Locations (1)

Great Ormond Street Hospital for Children NHS Trust

London, United Kingdom

Key Dates

Start Date

August 1, 2009

Primary Completion Date

February 1, 2011

Completion Date

August 1, 2013

Last Updated

March 2, 2022

Enrollment

ACTUAL participants

Conditions

Esophageal Atresia With Tracheo-esophageal FistulaCongenital Diaphragmatic Hernia

Interventions

Hypercapnia during thoracoscopy

PROCEDURE

Open surgery

PROCEDURE

An Exploratory Physiological Study of Post-operative Recovery in Surgical Neonates and Dimethylarginine:Arginine Levels

NCT06731855

GastroschisisCongenital Diaphragmatic Hernia+4 more

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RECRUITINGNA

Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH

NCT07166172

Congenital Diaphragmatic HerniaCongenital Abnormalities+6 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 2, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases

Inclusion Criteria

Exclusion Criteria

An Exploratory Physiological Study of Post-operative Recovery in Surgical Neonates and Dimethylarginine:Arginine Levels

Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH

Fetoscopic Endoluminal Tracheal Occlusion

Fetoscopic Endoluminal Tracheal Occlusion in Severe Left Congenital Diaphragmatic Hernia

Fetoscopic Endoluminal Tracheal Occlusion (FETO) for Congenital Diaphragm Hernia

Maternal-fetal Immune Responses to Fetal Surgery