18 years of age or older

KPS equal or greater than 60

Anatomopathological confirmation of GBM

Previous RT with therapeutic doses

At least 5 months from the end of RT course

Not a candidate to surgical resection

Patients with partial resection after resection of recurrent GBM will be allowed

Patients with local progression after resection of recurrent GBM will be allowed

Lesion with a maximal 150cc volume, as defined by enhancing portion in contrast enhanced MRI

Hemoglobin levels (Hb) equal or greater than 10ng/dl. Blood transfusions to correct the Hb will be allowed.

Hypofractionated Stereotactic Radiotherapy in Recurrent Glioblastoma Multiforme