A Clinical Study to Assess Two Doses of GSK2402968 in Subjects With Duchenne Muscular Dystrophy (DMD)

Exclusion Criteria

• •Any additional missing exon for DMD that cannot be treated with GSK2402968,
• •Current or history of liver disease or impairment including :
• •1. an INR vaue above 1.5 is in and of itself exclusionary
• •2. a total bilirubin greater than 2 times the Upper Limit of Normal is in and of itself exclusionary
• •3. a GGT greater than 2 times the Upper Limit of Normal is in and of itself exclusionary
• •Current or history of renal disease or impairment,
• •Baseline platelet count below the Lower Limit of Normal,
• •aPPT above the Upper Limit of Normal,
• •History of significant medical disorder which may confound the interpretation of either efficacy or safety data e.g. inflammatory disease
• •Acute illness within 4 weeks of the first anticipated administration of study medication which may interfere with study assessments,
• •Use of anticoagulants, antithrombotics or antiplatelet agents, previous treatment with investigational drugs, idebenone or other forms of Coenzyme Q10 within 1 month of the first administration of study medication,
• •Current or anticipated participation in any investigational clinical studies,
• •Positive hepatitis B surface antigen, hepatitis C antibody test (if verified via RIBA or PCA testing), or human immunodeficiency virus (HIV) test at screening,
• •Symptomatic cardiomyopathy. If subject has a left ventricular ejection fraction \<45% at Screening, the investigator should discuss inclusion of subject in the study with the medical monitor,
• •Children in Care. The definition of a Child in Care is a child who has been placed under the control or protection of an agency, organisation, institution or entity by the courts, the government or a government body, acting in accordance with powers conferred on them by law or regulation. The definition of a child in care can include a child cared for by foster parents or living in a care home or institution, provided that the arrangement falls within the definition above. The definition of a child in care does not include a child who is adopted or has an appointed legal guardian