Lead Sponsor

University Hospitals Cleveland Medical Center

Collaborators

Age

60 - No limit years

Sex

ALL

Healthy Volunteers

No

•Subjects must have type I Bipolar disorder by DSM-IV criteria confirmed on the Mini Neuropsychiatric Interview (MINI)
•Subjects must be age 60 or older
•Subjects must have sub-optimal response to current psychotropic management including at least one of the following:
•1. Behaviors and symptoms of irritability, agitation, mood lability or diminished ability to interact with others in their place of residence
•2. Diminished ability to take care of basic personal needs in their place of residence due to symptoms of BD

•History of intolerance or resistance to asenapine
•Clinical diagnosis of dementia or Mini-mental state (MMSE) \< 24
•History of TIA, stroke or MI within the past 12 months
•Medical illness that is the clear, underlying etiology of BD
•Unstable medical illness or condition including prolonged QT interval, which in the opinion of the study investigators, is likely to affect the outcome of the study or the subject's safety
•DSM-IV substance dependence (except nicotine or caffeine) within the past 3 months.
•Rapid cycling BD defined as 4 or more discrete mood episodes within the previous 12 months.
•At high risk for self-harm or suicide