A Study to Evaluate the Safety of Withholding Anticoagulation in Patients With Subsegmental PE Who Have a Negative Serial Bilateral Lower Extremity Ultrasound

Exclusion Criteria

• •1. Proximal lower extremity (popliteal vein or above) or upper extremity (subclavian vein or above) DVT.
• •2. Need for long term oral anticoagulant therapy for reasons other than VTE.
• •3. SSPE diagnosed in a hospitalized patient (\> 48 hours after hospital admission).
• •4. Requiring oxygen therapy to maintain an O2 saturation over 92%
• •5. Previous history of DVT (proximal or distal) of upper or lower extremities, PE, or unusual site thrombosis (e.g. splanchnic or cerebral vein thrombosis).
• •6. Geographically inaccessible for follow-up
• •7. Active Malignancy (defined as other than basal-cell or squamous cell carcinoma of the skin; cancer within the past 6 months; any treatment for cancer in the past 6 months; or recurrent or metastatic cancer)
• •8. Pregnancy
• •9. Have received more than 48 hours of therapeutic anticoagulation.
• •* Prophylactic dose allowed if required for separate indication and acceptable by the investigator.
• •10. Unable/refuse to sign informed consent
• •11. Asymptomatic SSPE (e.g. SSPE is an incidental finding on a CT scan conducted for reasons other than suspected PE)