Developed any of the following during Study-PR04409.3 or has begun taking hormone therapy other than WC3011:

Hypersensitivity to estrogen and/or progestin therapy

Known or suspected premalignant or malignant disease (except successfully treated skin cancers)

Manifestation of or treatment for significant cardiovascular disease, stroke or ischemic attack

Insulin-dependent diabetes mellitus

Smoking ≥ 15 cigarettes daily

Uncontrolled hypertension - systolic blood pressure (BP) ≥ 160 mmHG or diastolic ≥ 95 mmHg

Evaluate Long-Term Safety and Efficacy WC3011 (Estradiol Vaginal Cream)