Previous chronic treatment with alkali within the last 3 months (including sodium bicarbonate, calcium carbonate or baking soda)

bicarbonate level \<20 or \>25 mEq/L

New York Heart Association Class III or IV heart failure

Systolic blood pressure \>180 mmHg

Initiation of ESRD treatment planned within 6 months

Kidney transplantation

Treatment with immunosuppressives within the last 3 months

Alkali Therapy in Chronic Kidney Disease