A Study of LY2484595 in Healthy Subjects

Exclusion Criteria

• •Are currently enrolled in or discontinued within the last 30 days from a clinical trial involving an investigational drug or device or off-label use of a drug or device or are concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study
• •Have known allergies to LY2484595 or related compounds
• •Are persons who have previously completed or withdrawn from this study
• •Have an abnormality in the 12-lead electrocardiogram (ECG) (including but not limited to a Bazett's corrected QT \[QTcB\] interval \>450 milliseconds (msec) for men and \>470 msec for women) that, in the opinion of the investigator, increases the risks associated with participating in the study
• •Have a history within the last 2 years or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematologic, or neurologic disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the study medication; or of interfering with the interpretation of data
• •Show evidence of significant active neuropsychiatric disease
• •Regularly use known drugs of abuse and/or show positive findings on urinary drug screening
• •Show evidence of human immunodeficiency virus (HIV) and/or positive human HIV antibodies
• •Show evidence of hepatitis C and/or positive hepatitis C antibody
• •Show evidence of hepatitis B and/or positive hepatitis B surface antigen
• •Are women with a positive pregnancy test or women who are lactating
• •Intend to use and actually use over-the-counter or prescription medication or dietary supplements within 14 days prior to dosing (acetaminophen is permissible on an as-needed basis at less than 3 grams per day for less than 7 days)
• •Have donated blood of more than 500 milliliters (mL) within the last month
• •Have an average alcohol intake that exceeds 14 units per week, or are unwilling to stop alcohol consumption for 48 hours prior and during the inpatient confinement at the Clinical Research Unit (CRU) (1 unit = 12 ounces \[oz\] or 360 mL of beer; 5 oz or 150 mL of wine; 1.5 oz or 45 mL of distilled spirits)
• •Use herbal supplements, grapefruit juice, grapefruits, Seville orange juice, Seville oranges, or starfruit within 7 days prior to study dosing
• •Smoke more than 10 cigarettes per day currently and are unwilling to abide by the CRU guidelines
• •Are unwilling to refrain from daily consumption of real licorice