Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
State University of New York at Buffalo
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18-65 years
EDSS 0-6.5 (0-5.5 in the phase II of the study)
Diagnosis of relapsing MS according to the McDonald criteria (Polman et al., 2005)
1 relapse within the past 12 months or GAD positive lesion on an MRI within the past 3 months (only for phase II of the study)
Be on treatment with currently FDA approved disease-modifying treatments (excluding Tysabri or steroids (within the last 30 days prior to enrollment)
Evidence of ≥2 sonographic parameters of suspicious abnormal extracranial cerebral venous outflow (see Table 1 background and 1.5 section)
Normal renal function: creatinine clearance level of \>60
You may not be if
Relapse, disease progression and Tysabri and steroid treatment in the 30 days preceding study entry
Pre-existing medical conditions known to be associated with brain pathology (e.g., neurodegenerative disorder, cerebrovascular disease, positive history of alcohol abuse, etc.)
Severe peripheral chronic venous insufficiency
Abnormal renal function
Contrast allergy (anaphylaxis)
Not accepting to undergo the endovascular treatment
