Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Geha Mental Health Center
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Confirmed diagnosis of schizophrenia according to DSM-IV-TR criteria
2. Treatment-resistant schizophrenia, defined as: documented treatment failure (insufficient clinical response or severe adverse effects) of two antipsychotics (one of them should be atypical) for an adequate duration of 6 weeks and in a sufficient dose of at least 600 mg/day of chlorpromazine equivalent
3. Age 18-65 years
4. Basal PANSS \> 75
5. CGI-S \>3
6. Persistent positive psychotic symptoms, with rating scores of moderate or worse on at least two of four positive symptom items (delusions, conceptual disorganization, hallucinatory behavior, and suspiciousness/persecution) on Positive and Negative Syndrome Scale (PANSS).
7. Competent and willing to provide written, informed consent
You may not be if
1. Patients with concomitant treatment with lithium, anticonvulsants, antidepressants
2. Patients with underlying severe medical illness, such as cardiovascular disease, cerebrovascular disease, bone marrow suppression or epilepsy
3. A previous trial of clozapine or amisulpride
4. Any known contraindication for treatment with clozapine or amisulpride
5. Any woman who is pregnant or planning a pregnancy, and any woman of child bearing potential unless using adequate contraception
