* Normal tension glaucoma (NTG) is the major type of glaucoma in Korea. (over 90% of glaucoma type)
* Brimonidine (selective alpha 2 adrenergic agonist): neuroprotection effect by suppression of aqueous humor production and increasement of uveoscleral outflow
* Timolol (non selective beta blocker): suppression effect of aqueous humor production
* Combigan (fixed combination of brimonidine \& timolol): more lowering effect of intraocular pressure and enhancing the compliance of glaucoma patients
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
over 18 years old
baseline IOP under 22 mmHg,both anterior chamber angle \> Grade 3\~4 by Shaffer grading system
You may not be if
IOP over 22 mmHg by Goldmann applanation tonometer
other types of glaucoma except open angle
other IOP lowering treatment
chronic or recurrent Hx. of ocular inflammation
using contact lens
any other ocular disease that could affect visual field examination (diabetic retinopathy, macular disease, uveitis, scleritis, optic neuritis, anterior ischemic optic neuropathy)
intraocular or glaucoma surgery within 6 months
Hx. of allergic reaction to timolol or brimonidine
bronchial asthma
moderate to severe chronic obstructive pulmonary disease
