Corneal Sensation and Incidence of Dry Eye Post Refractive Cataract Extraction With FemtoSecond Laser

Exclusion Criteria

• •Uncontrolled inflammation not related to dry eye
• •Corneal abnormality that can affect corneal sensation or tear film stability (except superficial punctate keratitis (SPK)).
• •History of ophthalmic herpes simplex or zoster keratitis
• •OSDI score \> 32
• •Active ocular allergy
• •History of refractive surgery or any surgery involving conjunctival, arcuate or corneal incision
• •Contact lens wear during the study. Soft contact lens wearers should discontinue use at least two weeks prior to Screening visit. Rigid gas permeable (RGP) or hard contact lens wearers should discontinue use at least one month prior to Screening visit.
• •Dry eye secondary to Vitamin A deficiency, scarring, pemphigoid, alkali burns, Stevens-Johnson syndrome, trachoma, or irradiation.
• •Currently using, or have used within 14 days of study enrollment, any ocular medications other than artificial tears
• •Use of topical cyclosporine (Restasis) within three months of Screening visit.
• •Have an uncontrolled systemic disease (e.g., hypertension, diabetes) or the presence of any significant illness (e.g., serious gastrointestinal, renal, hepatic, endocrine, pulmonary, cardiac, neurological disease, cancer, AIDS, or cerebral dysfunction) that could, in the judgment of the investigator, jeopardize subject safety or interfere with the interpretation of the results of the study
• •Temporary or permanent occlusion of the lacrimal puncta
• •Require chronic use of systemic medications which may induce or affect a dry eye condition (e.g., anticholinergics, cyclosporine, antihistamines, antimuscarinics, beta-blocking agents, tricyclic antidepressants, phenothiazines, estrogen-progesterone, and other estrogen derivatives), unless that medication has been used in the same dose for at least 3 months and is expected to remain constant for the course of the study
• •Current or anticipated use of nutritional supplements (e.g. flax seed oil, fish oil, omega-3 supplements) which may affect a dry eye condition.
• •Are currently enrolled in any other clinical study or have participated in such a study within 30 days of entry into this study
• •Is pregnant, breast-feeding, planning a pregnancy, or not using a reliable method of contraception. Subjects who become pregnant during the study will be discontinued from further study participation.
• •Have a condition or are in a situation that, in the investigator's opinion, may put the subject at significant risk, confound the study results, or interfere significantly with their participation in the study.