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Efficacy of Gabapentin in Prevention of Tourniquet Pain and Hypertension | Clinical Trials | Clareo Health

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Efficacy of Gabapentin in Prevention of Tourniquet Pain and Hypertension

Efficacy of Gabapentin in Prevention of Tourniquet Pain and Hypertension During Orif of Tibia Fracture Under General Anesthesia

NCT01441531•Baylor College of Medicine

View on ClinicalTrials.gov

Summary

The purpose of the study is to find out if taking a dose of gabapentin 600 mg by mouth (po) before surgery will help prevent the development of tourniquet pain and hypertension while the tourniquet is inflated during orif of tibia fracture.

Eligibility

Age

18 - 64 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patient ages 18-64
•ASA physical status 1-3
•Schedule for orif tibia fracture with use of pneumatic tourniquet

Exclusion Criteria

•Allergy to study medications
•polytrauma
•lower extremity crush injury
•chronic opioid use
•sickle cell disease or trait
•peripheral vascular disease
•poorly controlled hypertension
•history of DVT/PE
•morbid obesity (BMI \> 35)
•patient or surgeon refusal
+1 more criteria

Locations (1)

Ben Taub General Hospital

Houston, Texas, United States

Key Dates

Start Date

January 1, 2012

Primary Completion Date

June 1, 2014

Completion Date

June 1, 2014

Last Updated

March 17, 2015

Conditions

Tourniquet-induced PainTourniquet-induced Hypertension

Interventions

gabapentin 600 mg po

DRUG

Placebo pill given one hour before surgery

DRUG