CNS Growth Factors Release and Changes in the Inflammatory Environment in Response to Electrical Stimulation in Subjects With Inflammatory Myelopathies
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Johns Hopkins University
FES cycling is a method of applying low level electrical currents to the leg and buttock muscles to cause the weakened or paralyzed muscles to contract and produce a cycling motion of the legs. The FES cycling in this study will be done through a device called the RT300-SL Cycle Ergometer (RT300).
Although this device has been cleared by the Food and Drug Administration (FDA) for use by individuals with neurological disorders, we are trying to find out the best way to use it in order to obtain the greatest results.
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male, Female, age 18-65, all ethnic groups
History of inflammatory myelopathy with onset at least 3 months prior
No FES ergometer (i.e. RT300 or equivalent) use within 1 month
Subject is medically stable, with no recent (1 month or less) inpatient admission for acute medical or surgical issues
Subject is legally able to make own health care decisions
Access to telephone with texting capabilities
English language proficiency
You may not be if
Cardiovascular disease as defined by previous myocardial infarction, unstable angina, requirement for anti platelet agents, congestive heart failure, or stroke New York Heart Association (NYHA) Class III or IV, history of arrhythmia with hemodynamic instability.
Uncontrolled hypertension (resting systolic BP\>160mmHg or diastolic BP \>100mmHg consistently)
Concurrent lower motor neuron disease such as peripheral neuropathy that would exclude lower extremity electrical excitability
Unstable long bone fractures of the lower extremities
Subjects who are unwilling to agree to two cerebrospinal fluid (CSF) examinations (lumbar punctures)
Presence of cardiac pacemaker and/or defibrillator
Presence of cancer
History of epileptic seizures
Subjects having a Stage 2 or greater sacral decubitus ulcer
